Why does celebrex require prior authorization

Fries JF. Nonsteroidal anti-inflammatory drug-associated gastropathy. Am J Med ; American College of Rheumatology Arthritis and Rheumatism. May ;64 5 Yeomans ND. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs. N Engl J Med ; Silverstein, et al. Gastrointestinal toxicity with celecoxib vs. JAMA ; Risk of cardiovascular events associated with selective COX-2 inhibitors.

Juni, et al. Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs. BMJ ; Solomon DH, et al. Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults.

Circulation ; 17 Greenwood Village, Colo: Thomson Healthcare. Updated periodically. A model was constructed to evaluate changes in utilization of therapeutically related drug classes eg, conventional nonsteroidal anti-inflammatory drugs [NSAIDs], gastrointestinal agents , office and emergency-department encounters, and hospitalizations before and after the PA policy was implemented on November 16, Results: After the PA policy was implemented, use of celecoxib was immediately reduced from 1.

Utilization changes were not observed in other drug classes. Similar changes were observed in the secondary analysis.

No other changes in medical service encounters were noted after the PA policy was activated. Conclusions: This observational study found that celecoxib use was substantially reduced after the implementation of a PA policy. No important changes in use of other drug classes were detected.